IL-22 Rabbit Polyclonal Antibody

IL-22 Rabbit Polyclonal Antibody

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IL-22 Polyclonal Antibody
ABP57408-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of IL-22 from Human, Mouse, Rat. This IL-22 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human IL-22

Polyclonal IL-22 Antibody
APR06857G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-22 . This antibody is tested and proven to work in the following applications:

IL-22 Polyclonal Antibody
ES8401-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against IL-22 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

IL-22 Polyclonal Antibody
ES8401-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against IL-22 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Polyclonal IL-22 Receptor Antibody
APR16820G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-22 Receptor . This antibody is tested and proven to work in the following applications:

Polyclonal IL-22 Receptor Antibody
APR16821G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human IL-22 Receptor . This antibody is tested and proven to work in the following applications:

IL-22 Antibody
7593-002mg 0.02 mg
EUR 206.18
Description: Interleukin-22 (IL-22) is a cytokine important for the modulation of tissue responses during inflammation (1). Unlike the distantly related IL-10, IL-22 does not inhibit the production of proinflammatory cytokines in monocytes in response to LPS, but it has some inhibitory effects on IL-4 production from Th2 T cells. IL-22 is expressed by both the adaptive arm of the immune system such as CD4 T cell subsets including Th17 cells, as well as by innate lymphocytes such as NK and LTi-like cells (2). IL-22 is highly expressed in several chronic inflammatory conditions, and studies suggest that IL-22 plays both inflammatory and protective roles (3).

IL-22 Antibody
7593-01mg 0.1 mg
EUR 523.7
Description: Interleukin-22 (IL-22) is a cytokine important for the modulation of tissue responses during inflammation (1). Unlike the distantly related IL-10, IL-22 does not inhibit the production of proinflammatory cytokines in monocytes in response to LPS, but it has some inhibitory effects on IL-4 production from Th2 T cells. IL-22 is expressed by both the adaptive arm of the immune system such as CD4 T cell subsets including Th17 cells, as well as by innate lymphocytes such as NK and LTi-like cells (2). IL-22 is highly expressed in several chronic inflammatory conditions, and studies suggest that IL-22 plays both inflammatory and protective roles (3).

IL-22 Antibody
R32873 100 ug
EUR 419

IL-22 Antibody
R32874 100 ug
EUR 419

IL-22 Antibody
R34201-100UG 100 ug
EUR 399

Il-22 Antibody
RQ4061 100 ug
EUR 419

IL-22 Antibody
RQ4626 100ug
EUR 419

IL-22 Antibody
F43455-0.08ML 0.08 ml
EUR 165

IL-22 Antibody
F43455-0.4ML 0.4 ml
EUR 379

Rabbit IL-22 ELISA Kit
ERTI0210 96Tests
EUR 625.2

Rabbit IL-22 Recombinant Protein
R00963-1 5ug/vial
EUR 310.8
Description: IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens, especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 likely plays a role in the coordinated response of both adaptive and innate immune systems.

ICP Quality Control Standard 22
QC-22 125ML
EUR 473.1

IL-22
E21-047 10ug
EUR 411.6

Anti-IL-22 Antibody
A00963 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for IL-22 Antibody (IL22) detection. Tested with WB in Human, Mouse, Rat.

IL-22 Receptor Antibody
24149-100ul 100ul
EUR 468

IL-22 Receptor Antibody
24153-100ul 100ul
EUR 468

IL-22 Receptor Antibody
2489-002mg 0.02 mg
EUR 206.18
Description: IL-22 Receptor Antibody: A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.

IL-22 Receptor Antibody
2489-01mg 0.1 mg
EUR 523.7
Description: IL-22 Receptor Antibody: A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.

IL-22 Receptor Antibody
2497-002mg 0.02 mg
EUR 206.18
Description: IL-22 Receptor Antibody: A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.

IL-22 Receptor Antibody
2497-01mg 0.1 mg
EUR 523.7
Description: IL-22 Receptor Antibody: A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.

Anti-IL-22 antibody
STJ97675 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-22.

IL-11, Interleukin-11, human
RC212-22 2ug
EUR 125.26

COVER GLASS, NO. 2, SQUARE 22 X 22MM
2855-22 50/pk
EUR 130.8
Description: Cover Glass; Cover Glass, CGW

COVER GLASS, NO. 1, SQUARE 22 X 22MM
2845-22 100/pk
EUR 134.4
Description: Cover Glass; Cover Glass, CGW

IL-22, Interleukin-22, human
RC212-33 2ug
EUR 125.26

IL-22, Interleukin-22, rat
RC252-33 2ug
EUR 125.26

IL-11, Interleukin-11, murine (mouse)
RC232-22 2ug
EUR 125.26

IL-22 Peptide
7593P 0.05 mg
EUR 197.7
Description: (IN) IL-22 Peptide

rHu IL-22
AK8355-0002 2µg Ask for price

rHu IL-22
AK8355-0010 10µg Ask for price

rHu IL-22
AK8355-0100 100µg Ask for price

rHu IL-22
AK8355-1000 1mg Ask for price

His-IL-22
E13-028-1 10μg
EUR 255.6

His-IL-22
E13-028-2 50μg
EUR 684

IL-22, Human
HY-P7039 100ug
EUR 1507.2

IL-22, Mouse
HY-P7079 50ug
EUR 1011.6

COVER GLASS, NO. 1 1/2, SQUARE 22 X 22MM
2850-22 100/pk
EUR 214.8
Description: Cover Glass; Cover Glass, CGW

ICP Quality Control Standard 22
QC-22-250 250ML
EUR 514.14

ICP Quality Control Standard 22
QC-22-500 500ML
EUR 615.6

Nori® Rabbit IL-22 ELISA Kit
GR144039 96-well
EUR 553.2

Recombinant Human Interleukin-22/IL-22
CH50-10ug 10ug
EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-22/IL-22
CH50-1mg 1mg
EUR 2983.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-22/IL-22
CH50-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Interleukin-22/IL-22
CH50-50ug 50ug
EUR 595.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Mouse Interleukin-22/IL-22
CM72-10ug 10ug
EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Interleukin-22/IL-22
CM72-1mg 1mg
EUR 2983.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Interleukin-22/IL-22
CM72-500ug 500ug
EUR 2106
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse Interleukin-22/IL-22
CM72-50ug 50ug
EUR 595.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Anti-IL-22/IL22 Antibody
A00963-1 100ug/vial
EUR 352.8

Anti-human IL-22 antibody
STJ15100103 250 µg
EUR 403.2
Description: This monoclonal antibody is suitable for detection of human IL-22 using Western blot.

Anti-human IL-22 antibody
STJ15100104 250 µg
EUR 440.4
Description: This monoclonal antibody is suitable for detection of human IL-22 using Western blot.

Anti-human IL-22 antibody
STJ15100105 250 µg
EUR 403.2
Description: This monoclonal antibody enables sensitive and specific detection of human IL-22 in immunoassays such as ELISA and ELISpot.

Anti-human IL-22 antibody
STJ15100106 250 µg
EUR 440.4
Description: This monoclonal antibody enables sensitive and specific detection of human IL-22 in immunoassays such as ELISA and ELISpot.

IL-22, human recombinant
4601-10
EUR 385.2

IL-22, human recombinant
4601-1000
EUR 9325.2

IL-22, human recombinant
4601-50
EUR 1246.8

IL-22, murine recombinant
4602-10
EUR 294

IL-22, murine recombinant
4602-1000
EUR 5997.6

IL-22, murine recombinant
4602-50
EUR 836.4

IL-22 Recombinant Protein
40-267-0002mg 0.002 mg
EUR 311.1
Description: IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant human IL-22 is a 33.6 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains.

IL-22 Recombinant Protein
40-267-001mg 0.01 mg
EUR 437.1
Description: IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant human IL-22 is a 33.6 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains.

IL-22 Recombinant Protein
40-426-0002mg 0.002 mg
EUR 311.1
Description: IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-beta/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant murine IL-22 is a 33.4 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains.

IL-22 Recombinant Protein
40-426-001mg 0.01 mg
EUR 437.1
Description: IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-beta/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant murine IL-22 is a 33.4 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains.

IL-22 Recombinant Protein
11-396 0.05 mg
EUR 714.3
Description: Interleukin-22 (IL22) is also known as cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor (IL-TIF), which is belongs to the IL-10 family or IL-10 superfamily (including IL-19, IL-20, IL-24, and IL-26), a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 biological activity is initiated by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.

IL-22 Receptor Peptide
2489P 0.05 mg
EUR 197.7
Description: (CT) IL-22 Receptor peptide

IL-22 Receptor Peptide
2497P 0.05 mg
EUR 197.7
Description: (NT) IL-22 Receptor peptide

IL-22 Recombinant Protein
90-515 25 ug
EUR 537.9
Description: Interleukin-22 (IL-22), also known as IL-10 related T cell derived inducible factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R(CRF29) and IL-10Rbeta(CRF24), belonging to the class II cytokine receptor family.

IL-22 Recombinant Protein
90-516 50 ug
EUR 651.3
Description: Interleukin-22 (IL-22), also known as IL-10 related T cell derived inducible factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R(CRF29) and IL-10Rbeta(CRF24), belonging to the class II cytokine receptor family.

IL-22 Recombinant Protein
90-519 25 ug
EUR 537.9
Description: Interleukin-22 (IL-22), also known as IL-10 related T cell derived inducible factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R(CRF29) and IL-10Rbeta(CRF24), belonging to the class II cytokine receptor family.

IL-22 Recombinant Protein
90-520 50 ug
EUR 651.3
Description: Interleukin-22 (IL-22), also known as IL-10 related T cell derived inducible factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R(CRF29) and IL-10Rbeta(CRF24), belonging to the class II cytokine receptor family.

IL-22 Recombinant Protein
90-523 10 ug
EUR 437.1
Description: Interleukin-22 (IL-22), also known as IL-10 related T cell-derived-inducible factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R(CRF29) and IL-10Rbeta(CRF24), belonging to the class II cytokine receptor family.

IL-22 Recombinant Protein
90-524 50 ug
EUR 821.4
Description: Interleukin-22 (IL-22), also known as IL-10 related T cell-derived-inducible factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R(CRF29) and IL-10Rbeta(CRF24), belonging to the class II cytokine receptor family.

IL-22 Recombinant Protein
91-037 0.05 mg
EUR 821.4
Description: Interleukin-22 (IL-22) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. Mouse IL-22 cDNA encodes a 179 amino acid residue protein with a putative 33 amino acid signal peptide that is cleaved to generate a 147 amino acid mature protein that shares approximately 79% and 22% sequence identity with human IL22 and IL10, respectively. IL22 has been shown to activate STAT-1 and STAT-3 in several hepatoma cell lines and up-regulate the production of acute phase proteins. IL-22 is produced by normal mouse T cells upon Con A activation. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R (previously an orphan receptor named CRF2-9) and IL-10R beta (previously known as CRF2-4), belonging to the class II cytokine receptor family.

IL-22 Recombinant Protein
92-266 0.05 mg
EUR 821.4
Description: Interleukin-22(IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.

IL-22 Recombinant Protein
92-661 0.05 mg
EUR 821.4
Description: Interleukin-22(IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.

IL-22 Recombinant Protein
92-662 0.05 mg
EUR 651.3
Description: Interleukin-22(IL-22) is a member of a group of the IL-10 family, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein, IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.

IL-22 Rabbit Polyclonal Antibody